Atopic dermatitis is a chronic inflammatory skin disease affecting 10-20% of children and 1-3% of adults worldwide. Pruritus (itch) prevalence in atopic dermatitis patients is greater than 80% and greatly impairs their quality of life by causing sleep and psychological disturbance.

Chronic hand eczema (CHE) is an underserved condition with high unmet need, impacting up to 10% of adults, with no approved treatments in the US and few available off-label options. CHE has a significant negative impact on quality of life, including psychosocial health and workforce productivity, and can lead to a number of comorbidities such as sleep disturbance and depression.

Osteoarthritis (OA) is a degenerative joint disease with no approved disease modifying therapies. OA is a major cause of disability and impaired quality of life affecting more than 230 million patients globally.